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The affected endothelial cells undergo apoptosis

The directionality of this relationship is debated: low testosterone may cause metabolic dysfunction, metabolic dysfunction may suppress testosterone, or both may be downstream of common upstream causes

Outcomes Changes in skin condition and clinical photography were assessed with blinded evaluation by a trained objective grader at baseline, and at immediate (1 h and 1 day) and long-term (7 days and 28 days) time points post treatment

Body temperature was not significantly affected by infection in this model

The antioxidant activity is especially critical for the operation of glutathione peroxidase (GPx), an enzyme that catalyzes the reduction of peroxides using GSH as an electron donor, oxidizing it to its disulfide form, GSSG (glutathione disulfide)