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Glutamate from the synapse binds to the receptor and causes an influx of ions (Na + , K + , and sometimes Ca 2+ ) into the cell.[ref][ref] There are three types of ionotropic glutamate receptors: 1) AMPA Receptors (GluA1-4): The AMPA receptor is encoded by the GRIA1- 4 genes, with multiple proteins being assembled together in the ER to make up the receptor