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It serves as a protective mechanism to regulate the passage of substances across the BBB and prevents physiologically irrelevant molecules in the peripheral circulation from entering the brain

Nucleic Acids 22 , 530541 (2020)

Moreover, emerging research suggests that metabolites of heme iron may increase CVD risk by promoting inflammation and adversely altering blood lipid profiles

IL-13, Interleukin-13

If tagged with monomeric-enhanced green fluorescent protein, one can see that the activation of Cdc42 is limited to just the stimulated spine of a dendrite