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Description

Dietary administration of broccoli seeds induced a significant increase in activities of the phase II detoxification enzymes NAD(P)H dehydrogenase, quinone 1 (NQO1), and GSTs (that are downstream targets of Nrf2) in stomach, small intestine, and liver tissues of wild-type mice, but not in Nrf2 KO mice [69]

Indeed, if the GSTM2 enzyme catalyses the breakdown of this conjugate in a manner comparable to that of GSTM1, the functional similarity between these two isozymes would be established