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Description

This difference may primarily be due to the auto-activation and subsequent degradation of hHPN WT (Vu et al

As demonstrated by genome-wide analyses (chromatin immuno-precipitation, DNA microarray, high-throughput sequencing) persistent histones are not randomly distributed, suggesting that their persistence is not a consequence of a histone replacement defect and that they are not simply remnants of the sperm differentiation program [60, 61]