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Description

Cyanocobalamin is the main ingredient in many B12 supplements

While its primary action involves p53 release, the modulation of FOXO4-related pathways intersects with cellular stress-response systems

The schedule below assumes the separate-vial approach, which is also what the staggered titration is built around

The reduced GSAAT(C168S), GSAAT(C190S) and GSAAT(C396S) mutants, as well as the double mutant GSAAT(C168S/C190S), each exhibited only half as much activity as that measured in the presence of DTT or TRX-f1 ( Figures 6B, C )