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Amifostine at a dose of 25 mg/kg significantly reduced oxaliplatin-induced c-Fos, nitrotyrosine, and activating transcription factor 3 (ATF3) expression, showing protective effects against nitrosative stress, neuronal hyperactivation and neuronal damage to dorsal root ganglion neurons in mice [147]

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Nonetheless, more recent studies have suggested that supplemental coenzyme Q 10 could promote mitochondrial biogenesis and respiration (18, 19) and delay senescence in transgenic mice (19)