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doi: 10.1016/j.semcancer.2022.11.007 97 BaumannFLeukelPDoerfeltABeierCPDettmerKOefnerPJet al

Inhibition of alpha-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors

Staroverov, V

Studies have found that ER stress promotes apoptosis, as evidenced by the upregulation of apoptosis markers such as Caspase-3 and Bcl-2-associated X protein (Bax)/B-cell lymphoma 2(Bcl-2) [85]