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Thigh - give injections in the outer middle third of the thigh

Jab #2 didn't go so well

Upon activation by toll-like receptor 4 (TLR4) and the receptor for advanced glycation end products (RAGE), macrophages initiate the synthesis of interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-), and other inflammatory biomarkers, resulting in further hepatic injury (Guilliams and Scott 2022)

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Although a small number of randomized trials investigating metformin use in patients with CRC are ongoing, these are in unselected populations and may also include other interventions (such as aspirin and physical activity)