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[ 266 ] Cells deploy multiple defense mechanisms to counterbalance lipid peroxidation, including the GSHdependent decrease of phospholipid hydroperoxides mediated by glutathione peroxidase 4 (GPX4) (GSHGPX4 pathway), [ 267 ] restraint of labile iron via ferritin and ferroportin (ferritinferroportin pathway), [ 148 , 268 ] the capture of lipophilic radicals via ubiquinol (coenzyme Q [CoQ]) and its oxidoreductase ferroptosis suppressor protein 1 (FSP1) (FSP1CoQ pathway), [ 269 , 270 ] along with the tetrahydrobiopterin (BH4) system

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