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doi: 10.1016/j.cub.2016.05.070 132 CantonMSnchez-RodrguezRSperaIVenegasFCFaviaMViolaAet al

However, autophagy during prolonged stress can lead to cell death

L-carnitine, a water-soluble quaternary ammonium compound, is an essential factor for the entry of long-chain FAs into the mitochondrial matrix ( In vitro experiments showed that PARL segregated from PHB2 in an in vitro model of HG/FFA-induced cardiac microvascular ECs in mice, decreased the expression of PINK1, Parkin, and LC3BII, reduced the co-localization of Parkin and mitochondria, inhibited mitophagy, and accelerated the injury of cardiac microvascular ECs in mice