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In addition, our neurosphere co-culture assay revealed that high glucose-treated hippocampal neurons directly interact with NSCs and inhibit neurite elongation via RGMa

Another says intramuscular for their B-12 shots and sends huge needles which for me are just a no-go

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The target itself was validated by a 2014 Nature study showing NNMT knockdown in mouse fat and liver protected against diet-induced obesity by augmenting cellular energy expenditure (Kraus 2014, PMID 24717514) [2]