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[28] The two primary metabolic routes that convert dopamine into HVA are: [29] Dopamine DOPAL DOPAC HVA catalyzed by MAO, ALDH, and COMT respectively Dopamine 3-Methoxytyramine HVA catalyzed by COMT and MAO+ALDH respectively In clinical research on schizophrenia, measurements of homovanillic acid in plasma have been used to estimate levels of dopamine activity in the brain

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doi: 10.3109/09637486.2015.1077787 155

216 (Springer Publishing Company, 2016)

Sleep and exercise are key, as is stress management, so consider mindfulness practices, regular physical activity and good sleep environments