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Apoptosis and glutathione: beyond an antioxidant Cell Death & Differentiation Glutathione Depletion Pathways 1. Precursor Depletion Key bottleneck: Cysteine availability. Source: Diet or hepatic transsulfuration (methionine homocysteine cysteine). Failure mode: Downregulation of cystathionine lyase (CSE) during Unearthing the secrets of mitochondrial ROS and glutathione in bioenergetics: Trends in Biochemical Sciences Epilepsy, ferroptosis and mitochondrial dysfunction. GPX4, glutathione Download Scientific Diagram Pleiotropic effects of a mitochondrion targeted glutathione reductase inhibitor on restraining tumor cells ScienceDirect
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