glutathione synthetase deficiency frequency Frontiers Glutathione deficiency induces epigenetic alterations

demonstrated that the cell-cycle-related gene Wee-1 , which contains three B-boxes in its promoter and encodes a protein kinase that inactivates the CDC2/Cyclin B1 complex, thereby delaying or preventing entry into mitosis, is under the direct transcriptional control of CLOCK:BMAL1 25

Biochim Biophys Acta 1379(2):233244

found that the N protein can undergo phase separation with TAK1 and IKK, concurrently suppress stress granule formation, promote NF-B activation, and ultimately trigger cellular pyroptosis (Fig

Diabetes Complications 28 , 399405 (2014)

Maiti A, Kantarjian HM, Popat V, Borthakur G, Garcia-Manero G, Konopleva MY, MD, DiNardo CD, Verstovsek S, Andreeff M , Kadia TM, Afujo HO, Goswamy GV, Blanco C, Velasquez M, Daver NG, Pemmaraju N, Pierce S, Wierda W, Kornblau S, Ravandi F, Cortes JE