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A shift in mitochondrial substrates and metabolic inflexibility causes DNA mutations, oxidative stress, and apoptosis in PTPMT1 knockout cells

Interestingly, ferroptosis and pyroptosis may be somehow connected, although the exact nature of their relationship remains to be elucidated

2.5 ALT and AST enzyme activity measurement To evaluate the degree of hepatic injury, the serum enzyme activities of key hepatic enzymes, including alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were assessed

ALS-causative mutations in FUS/TLS are shown to abnormally enhance their interaction with SMN and dysregulate its function, including loss of Gems and altered levels of small nuclear RNAs