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When pregnant, a woman with a low-functioning thyroid will also need to increase her dosage of thyroid hormone

doi: 10.1016/j.intimp.2021.107725 220 WanrooyB

Another possible mode of immune activation in the brain is the role of TLR7, a key regulator of innate and adaptive immune responses, which is highly expressed in females in contrast to males, males also display higher angiotensin-converting enzyme 2 (ACE2) than females and the nuclear fertility restorer gene (RF5) which drives interferons, is higher in females