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The pathogenesis of MTX-induced renal impairment is thought to be mediated by either MTX and its metabolites precipitating in the renal tubules or MTXs direct toxic impact on the renal tubules (Reference Widemann and Adamson6)

CYP1A2 displayed stable expression across Days 730, while CYP1B1 and CYP4F12 exhibited progressive increases, reaching maximum levels at Day 45, reflecting roles in fatty acid and bile acid metabolism during later stages

doi: 10.3389/fnins.2014.00447 217 WuX.ChiF.WangB.LiuS.WangF.WangJ.et al

Among these, Asian countries (n = 4), European countries (n = 3), North American countries (n = 1), African countries (n = 1), and South American countries (n = 1) dominate the top 10 regions based on the total number of publications (Table 1)

Your health care provider needs to know if you have any of these conditions: kidney disease