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Collectively, these recent contributions argue that future GSH-centric redox sensing and nanomedical approaches should (i) incorporate organelle targeting (especially mitochondria) to exploit subcellular redox heterogeneity, (ii) embed analyte-responsive activation into both therapeutic and imaging components, (iii) combine biochemical sensing with optical or thermal engineering for spatiotemporal control, and (iv) favor clinically translatable carriers (e.g., PLGA) for delivery

In the lower range of values of S , GSH increases rapidly as S increases

BmK AGAP, a potential candidate molecule, has demonstrated heterologous expression and maintained its pharmacological effects while increasing its yield

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