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NADs that express proteins mRNA, a single-stranded polynucleotide that carries genetic information, is essential for expressing encoded proteins within cells, thus exerting corresponding biological functions via these proteins

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In turn PDK1 phosphorylates Akt in T308 (46), however the maximal activation of Akt requires its additional phosphorylation on S473 located at the carboxyl-terminus site, mediated by mTORC2 (47)

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