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When the role of bilirubin was investigated in a mouse model with moderately elevated bilirubin concentrations, a protective effect against angiotensin II-dependent hypertension, a reduction in glomerular filtration and renal blood flow was found ( 38 , 87 )

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Also, it was observed that some isoforms containing a cysteine exhibit a more diversified activity profile, as they possess deglutathionylation activity in addition to the peroxidase and GSH-conjugation activities (Pgeot et al., 2017)

We selected the pink module (r = 0.69, p = 4e161), which showed the most positive correlation with UC, and the blue module (r = -0.46, p = 1e59), which showed the most negative correlation with UC as key modules ( Figure 3C )