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Therefore, the anti-HCC effect of galunisertib should be further investigated in preclinical and clinical studies to determine the best therapeutic regimen with the ability to improve the survival and quality of life of patients with HCC

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Drugs such as -agonists and -antagonists have been shown to affect the incidence of PD in opposing directions, with -agonists seeming to be somewhat protective (121, 122)

Potassium disulfite (CAS No.: 16731-55-8, purity 98%), polyvinylpolypyrrolidone (PVPP, CAS No.: 9003-39-8, purity 98%), syringaldazine (purity 98%), L-ascorbic acid (purity 99%), L-glutathione reduced (purity 98%), and FeSO 4 7H 2 O (purity 99%) were purchased from Sigma-Aldrich (Madrid, Spain)