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The model showed R2 and Q2 values of 0.99 indicating a good classification performance and validated using permutation test with 20 times and CV-ANOVA which demonstrated that the model is not over fitted (Supplementary Fig

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This effect seems universal as overexpression of SIRT7-WT and SIRT7-2E also inhibited AKT phosphorylation in HEK293 cells (Supplementary Fig

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