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5 Conclusions and perspectives HO-1 plays a dual role in atherosclerosis, particularly in the regulation of ferroptosis, which presents both therapeutic opportunities and challenges ( HO-1 can exert both beneficial and harmful effects at different pathological stages, making the regulation of its temporal and spatial expression crucial

Both are common feelings due to how unpredictable these conditions are and most people have more questions than answers regarding them

Asian Pac J Health Sci

The PI3K/Akt/mTOR pathway 20 along with the p38 MAPK, ERK1/2 and STAT3 signaling axis 21 have been implicated in controlling glycolytic phenotypes of the tol-DC, but the role for AMPK in both immunologic and tol-DC biology is largely understudied, and the precise role of mTOR/AMPK balance is controversial 4,13

doi: 10.1007/s00259-012-2110-3 317 PfallerM