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Like most chemical modifications, such as and m 5 C, m 6 A in mRNA did not induce IFN- secretion, in contrast to unmodified RNA [217]

The C201-harboring loop is also well-ordered in all three structures with the same degree of dynamical disorder found in the wild-type enzyme

The ERAD protein complex SEL1L-HRD1 directly interacts with and mediates targeted degradation of basal inactive STING thereby limiting the activatable STING pool and preventing overactivation of the immune response (167)