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Iron Iron is necessary for hamoglobin formation

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2 Patients describe: Stabbing, burning, or electric-shock pain traveling from the base of the neck, through the inner upper arm, down the ulnar forearm, and into the ring and little fingers Numbness or pins and needles sensation in these same areas, often worse at night or upon waking Temperature sensitivity changes , with some patients reporting that their affected fingers feel colder than the others Intrinsic Hand Muscle Weakness: The Grip Strength Problem Because the C8 nerve root is predominantly composed of motor fibers controlling intrinsic hand muscles, weakness is a prominent and concerning feature of C7-T1 disc problems

Loss of methylation of the ICR1 on the paternal allele results in the phenotype of Silver Russell syndrome (SRS) which may also arise from other genetic aberrations that have not yet been linked to the IGF-II production or signaling cascade including maternal uniparental dyssomnia of chromosome 7

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