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Description

These observations provide strong evidence for the proposed mechanism of action of these dual covalent degraders: covalent engagement of the target protein to lock it, followed by proteasomal degradation triggered by covalent modification of E3 ligases

95% CI: 1.00 - 2.90

NLRP3 then undergoes dimerization and recruits ASC through homotypic pyrin domain-pyrin domain interactions, thus promoting oligomerization and formation of a larger complex