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This therapy involves implanting electrodes connected to a pulse generator to deliver electrical signals to specific brain targets, thereby modulating neural circuits [197, 198]

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Additionally, peripheral inflammatory markers, including IL-2, IL-17A, IL-12p70, tumour necrosis superfamily member 8 (TNFRSF8) and tumour necrosis factor (TNF)-, are associated with neurodegeneration in individuals with FTLD, such as brain atrophy and abnormal metabolism, which are mainly distributed in frontaltemporal regions