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Third, it can interfere with the signaling pathways involved in platelet activation, such as the PI3K/Akt and MAPK pathways (150, 151)

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This is also further supported by the identification of the human DMRTA2 R116P point mutation reported here that, to our knowledge, is the only mutation in DMRTA2 suggested to play a role in microcephaly by affecting its ability to bind DNA