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Disclosure of interest: All authors: nothing to disclose Scientific Communications: acute 01.00 - ACUTE ISCHEMIC STROKE MANAGEMENT - 01.01 - ACUTE MANAGEMENT - Neither thrombolysis nor thrombectomy O - ESOC25-1173 EDARAVONE DEXBORNEOL IN LARGE ISCHEMIC STROKE: REAL-WORLD EXPERIENCE FROM MULTICENTER IN CHINA Yingting Zuo 1 , Gaoting MA 1 , Ran Mo 1 , Yifan Wu 1 , Haiqing Song 1 , Lianmei Zhong 1 1 Xuanwu Hospital Capital Medical University, Beijing, China Background and Aims: Edaravone dexborneol, a novel brain cytoprotection with combined antioxidant and anti-inflammatory properties