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In addition, participants who had the following conditions were prohibited from entering the study: (1) history of various inflammatory, cancer, cardiovascular, liver, diabetes, kidney, infectious, and gastrointestinal diseases, (2) use or history of use during the last 3 months of all types of supplements or drugs affecting appetite, weight, or metabolism, (3) receiving or following dietary and exercise treatments affecting weight during the last 6 months, and (4) Alcohol intake and smoking

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Cell culture studies using adipocytes have shown that NNMT overexpression promotes lipid accumulation and insulin resistance, while NNMT knockdown or inhibition increases NAD+ levels, activates SIRT1, enhances mitochondrial respiration, promotes expression of thermogenic genes including UCP1, and drives white adipocyte browning toward a beige phenotype

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Therefore, even if the relevance for humans of such tumors has not been determined, GLP1RAs are contraindicated in patients with a family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2 (64)