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To date, vitamin B12 is officially included as supplement to pemetrexed treatment (a chemotherapeutic used in pleural mesothelioma and non-small cell lung cancer because of its folate similarity and inhibition of purine and pyrimidine synthesis)

Absolute contraindications require practitioner discretion

In addition to encouraging apoptosis, miR-6881-3p also influences GCs by modifying the expression of gonadotropin receptors (follicle-stimulating hormone receptor, or FSHR), luteinizing hormone/choriogonadotropin receptor, or LHCGR, and enzymes that produce steroid hormones, like cholesterol side-chain lyase (cytochrome P450 family 11 subfamily A member 1, or CYP11A1)

[DOI] [PubMed] [Google Scholar] 78

"Vitamin B12 Deficiency and the Nervous System: Beyond Metabolic DecompensationComparing Biological Models and Gaining New Insights into Molecular and Cellular Mechanisms"