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Exacerbation of alcohol-induced oxidative stress in rats by polyunsaturated Fatty acids and iron load

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In particular, compared to the mild degeneration group, the expression levels of ferroptosis driver genes ( ACSL4 , SLC39A14 , and CHAC1 ) were relatively higher in the severe degeneration group, whereas the expression levels of ferroptosis suppressor genes ( GPX4 , FTH1 , and HSPB1 ) were significantly lower (Fig