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The key features that usually distinguish CFS/ME from other fatiguing illnesses are: post-exertional malaise (PEM) (immediately or delayed 24 hours or more) symptom exacerbations in response to stressors (physical or mental overexertion, new infections, sleep deprivation, immunisations, or other medical comorbidities)

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The association between BPC-157 and the NO-eNOS pathway has often been made in relation to its effects on endothelial nitric oxide formation

In published studies, the fragment has not demonstrated meaningful impact on blood glucose, insulin sensitivity, or IGF-1 concentrations at research-relevant doses

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