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Swerdlow and Khan (2004) and Swerdlow et al

Non-nuclear reads and unmapped paired reads were discarded, and duplicate reads were removed using Picard MarkDuplicates

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We assume that noise of the measured signals is log-normally distributed with constant standard deviation

2.7.5 Other regulatory mechanisms Exosome, small vesicles containing RNA and proteins, serve as important mediators of intracellular communication, immune responses, and cellular regulation (Wang and Zhu, 2019