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Although peripheral 5-HT cannot cross the BBB directly, it influences CNS function indirectly by activating vagal afferent fibers, modulating immune cells, and affecting tryptophan availability ( 4.1.2 The GABA pathway Beyond the 5-HT system, GABA, as the most abundant inhibitory neurotransmitter in the CNS, has a core role in mood regulation and anxiety control

HUBERMAN: My whole purpose in doing this episode is to highlight how these different molecules ought to work, how they've been shown to work in animal models, and therefore how they might be working in humans

doi: 10.3389/fnut.2021.759507 Received 16 August 2021 Accepted 18 October 2021 Published 25 November 2021 Volume 8 - 2021 Edited by Xian Wu, Miami University, United States Reviewed by Maria Elisa Drago-Serrano, Universidad Autnoma Metropolitana Unidad Xochimilco, Mexico

Luciferase activity was expressed as the ratio of firefly luciferase to renilla luciferase and normalized to the control group