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However, several conditions can increase the susceptibility to acetaminophen hepatotoxicity, such as malnutrition, chronic illness, and chronic ethanol ingestion, and the toxic dose of acetaminophen may be lower in these patients

2023 December 64 (12):1992-2001

[DOI] [PubMed] [Google Scholar] 511.Kocki T., Wielosz M., Turski W.A., Urbanska E.M

doi: 10.1038/nrd3003

Transmission electron microscopy (TEM) revealed an increase in autophagosomes, while immunofluorescence analysis showed enhanced colocalization of LC3B with MitoTracker-labeled mitochondria (marking mitophagosomes) in M9a+sh EPAS1 cells, further indicating enhanced mitophagy (Fig