glutathione synthetase deficiency snps Critical Roles of the Cysteine–Glutathione Axis in the Production of γ-Glutamyl Peptides in the Nervous System Deficient Glutathione in the Pathophysiology

P., & Puigserver, P

To systematically identify GSH-sensitive chemotherapeutics, we constructed GSH-depleted HCC cells through infection of ChaC1-expressing adenovirus (Ad-ChaC1)

One of these unique types is a heterogeneous collection of circular DNA molecules (type 4) while the other is a heterogeneous collection of linear molecules (type 6)

This trend was consistent with the Venn diagram (Fig

Antioxidant defense systems include GPX4 (which reduces lipid hydroperoxides to non-toxic lipid alcohols using GSH), the cystine/glutamate antiporter system Xc (composed of SLC7A11 and SLC3A2, which imports cystine for GSH synthesis), and the newly identified ferroptosis suppressor protein 1 (FSP1, also known as AIFM2) (Wang et al., 2024