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Journal of Clinical Investigation 2003;112:892-901

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seems to occur through the activation of protein kinase RNA-like ER kinase (PERK) and HSP90, important stress sentinel proteins, and chaperones

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The review confirmed TB4s role in binding G-actin and promoting cell migration including the mobilisation, migration, and differentiation of stem and progenitor cells that form new blood vessels and regenerate damaged tissue

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This results in restricted glutamine metabolism in immune cells, diminishing their anti-tumor efficacy and promoting immune evasion (57) ( Figure 2 )

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