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doi: 10.1016/j.molcel.2014.03.026 67 MeriniW.CalonjeM

This is particularly problematic for oral ingestion because the gastrointestinal tract is unfavorable for curcumins stability, as will be discussed below

When joint aches do occur temporally alongside B12 therapy, they are more likely coincidental or related to other factors rather than a direct pharmacological effect of the vitamin itself