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3 Results and Discussion 3.1 Fragment Screening: 12 Hits Identified in 5 Sites Crystallographic fragment screening performed at the XChem facility allowed us to test 352 small compounds from the DSiP library, a collection specifically designed to ensure rapid and cheap follow-up synthesis ( Data analysis, performed by the PanDDA algorithm (Figure 1), described later in detail

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Nature 458 , 719724 (2009)