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Article contents Abstract Introduction Urolithin A: sources, dosage and mechanism of action Spermidine: sources, dosage and mechanism of action Urolithin A and spermidine in autophagy and mitophagy: studies in vitro In vivo studies on urolithin A and spermidine Clinical studies on urolithin A and spermidine Conclusions Financial support Competing interests Authorship Consent for publication Declaration of generative AI and AI-assisted technologies in the writing process References Distinct roles of urolithin A and spermidine in mitophagy and autophagy: implications for dietary supplementation Published online by Cambridge University Press: 17 December 2025 Abstract Introduction Urolithin A: sources, dosage and mechanism of action Spermidine: sources, dosage and mechanism of action Urolithin A and spermidine in autophagy and mitophagy: studies in vitro In vivo studies on urolithin A and spermidine Clinical studies on urolithin A and spermidine Conclusions Financial support Competing interests Authorship Consent for publication Declaration of generative AI and AI-assisted technologies in the writing process References Abstract The increasing focus on longevity and cellular health has brought into the spotlight two key compounds, urolithin A (UroA) and spermidine, for their promising roles in autophagy and mitophagy

WG: Sadly, this is the corner theyve backed themselves into, so for the most part this is a little bit of what we see is what we get

The FDA Peptide Regulations Explained: What's Legal, What's Not, and What's Coming A comprehensive analysis of current FDA peptide restrictions, enforcement reality, and future regulatory changes This is one of the most comprehensive pieces weve put together at ThePeptideList

Sources Buckley ST, et al

The few dollars you save on discount water could cost you hundreds in wasted peptides or compromised research