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10.1016/j.mam.2005.07.003 12 AsefyZ.KhusroA.MammadovaS.HoseinnejhadS.EftekhariA.AlghamdiS.et al (2021)

A large body of research (1) confirms that folate deficiency something that is incredibly common is frequently seen in those with depression, and is remediated with the supplementation of this nutrient

The selectivity profile against related SAM-dependent methyltransferases has been characterized in the same publication series

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2.5 Disrupted proteostasis and autophagy-lysosomal dysfunction The autophagy-lysosomal pathway (ALP) and ubiquitin-proteasome system (UPS) are critical for degrading misfolded proteins