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7-DHC functions as an intrinsic inhibitor of ferroptosis by incorporating into cellular membranes and selectively neutralizing lipid peroxyl radicals via the conjugated double bonds in its B-ring

Whereas accumulation of mHtt led to decrease in antioxidant protein peroxiredoxin Prx1, the overexpressed wild-type Prx1 significantly reduced mHtt-induced toxicity (Pitts et al., 2012)

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Proc Nat Acad Sci U S A 106:91099114 Meyer AJ, Hell R (2005) Glutathione homeostasis and redox-regulation by sulfhydryl groups