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This approach has been successfully translated into the clinic as the administration of low-dose IL-2 in patients with cGvHD resulted in great responses owed in part to the promotion of thymic differentiation and peripheral expansion, survival and function of nTregs [49, 50]

Among these, the activating transcription factors (ATFs) have emerged as pivotal integrators of immune and metabolic cues, orchestrating macrophage responses under diverse physiological and pathological conditions

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(106) irradiated individual cells with X-rays of less than 0.5 Gy and found that the likelihood of inducing bystander effects increased with increasing radiation dose, whereas once a response was induced, their effects were nearly equal