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Experimental research using in vivo and in vitro systems provides causal evidence for these synergistic mechanisms by identifying shared molecular pathways and stress responses, whereas large-scale epidemiological studies predominantly yield correlational data linking combined exposures to heightened cancer incidence [262,263]

SLC30A10 is a cell surface-localized manganese efflux transporter, and parkinsonism-causing mutations block its intracellular trafficking and efflux activity

The inclusion of participants experiencing these hormonal changes may be another limitation of the study

Progress should be assessed through body composition analysis, circumference measurements, and photos rather than scale weight alone, as muscle preservation can mask fat loss on the scale