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Plasmodium infection inhibits tumor angiogenesis through effects on tumor-associated macrophages in a murine implanted hepatoma model

The canonical pathway is primarily triggered by MSU crystals through NLRP3 inflammasome activation and caspase-1 signaling, whereas the non-canonical pathway is mediated by caspase-4/5 in humans (caspase-11 in mice) in response to intracellular LPS

Anti-CTLA-4 combined with anti-VEGF mAb NCT00790010 is a phase I clinical trial to explore the effect of ipilimumab (anti-CTLA-4) plus bevacizumab (anti-VEGF) in metastatic melanoma patients [85]

The Contribution of Homocysteine Metabolism Disruption to Endothelial Dysfunction: State-of-the-Art

Cushing Syndrome, Journal of the American Medical Association (2023)