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[10] [9] REDEFINE 5 [edit] In April 2026, results were published in The Lancet on REDEFINE 5, a 68-week, double-blind, phase 3a clinical trial enrolling 331 participants

The researchers believe svL4 serves as a substrate for transglutaminases (TGMs), enabling cross-linking of structural proteins to reconstruct a functional stratum corneum