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903 In a RANKL-induced osteoclast model, the bisphosphonate zoledronic acid promotes ferroptosis by increasing Fe 2+ , ROS, and MDA levels, and decreasing GPX4 and GSH levels

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Numerous studies have demonstrated that polyphenols exert cytotoxic effects on various cancer cell lines and possess significant antioxidant activity (287, 288)

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Haataja L, Manickam N, Soliman A, Tsai B, Liu M, Arvan P (2016) Disulfide mispairing during proinsulin folding in the endoplasmic reticulum