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J Clin Invest 113 : 96105 Clemmons DR et al

Bupropion/Naltrexone Sustained Release (SR) The combined bupropion/naltrexone (NB) therapy induced significantly greater weight loss on a diet and exercise program over 56 weeks compared to monotherapy and placebo (61)

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Beta-3 adrenergic pathway Mouse studies show the peptide raises expression of beta-3 adrenergic receptors, the main lipolytic receptors on fat cells, helping fat tissue respond more strongly to fat-burning signals